克罗米酚对男性低促性腺素高血压减退症有效

洛杉矶（伦敦证券交易所社健康初版）1年末四日华盛顿邮报：据发表在12年末出初版的《生子与子代》年末刊的一项简报指出克罗米酰对大多高促性腺芝性动态大不如在此之前的年长病人不利。来自伯明罕密苏里大学的该简报的第一著者Scott J. Whitten助手在不能接受伦敦证券交易所新闻网站报导谈到是：“病变或获得性HH病人在不能接受侵害性较小和比较昂贵的病患（例如注射促性腺激芝类）在此之前进行时4个年末的克罗米酰试验性病患是不利的。”Whitten助手和上司研究了克罗米酰对10名HH年长病人（HH是导致年长子代的少见因芝）是否有效。简报所称克罗米酰病患1年后，4名卡尔曼(氏)综合征病人中只有一名病人的体内pH增加而全垂体动态大不如在此之前症病人的体内依赖症状均没得不到改善。意味著，该简报指出3名成年发病的病变HH年长病人经过3个年末克罗米酰的病患体内pH有了明显增加。目在此之前该组病人已有两名直至了早产。Whitten助手说是：“除非对克罗米酰病患没反应，我们不会因为过敏反应停止对病人使用该药物。”最后著者总结说是：“因为有条件有限，对HH病人促性腺激芝类药物和克罗米酰的随机研究较难进行时，然而利用多系列的严格考虑标准对病人进行时标准可能帮助进一步可验证克罗米酰直至年长高早产的实证。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色幻想

编辑： 张靖